• Community carriage of ESBL-producing Escherichia coli and Klebsiella pneumoniae: a cross-sectional study of risk factors and comparative genomics of carriage and clinical isolates 

      Raffelsberger, Niclas Peter; Buczek, Dorota Julia; Svendsen, Kristian; Småbrekke, Lars; Pöntinen, Anna Kaarina; Löhr, Iren Høyland; Andreassen, Lotte Leonore Eivindsdatter; Simonsen, Gunnar Skov; Sundsfjord, Arnfinn Ståle; Gravningen, Kirsten; Samuelsen, Ørjan (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-12)
      The global prevalence of infections caused by extended-spectrum βlactamase-producing Enterobacterales (ESBL-E) is increasing, and for Escherichia coli, observations indicate that this is partly driven by community-onset cases. The ESBL-E population structure in the community is scarcely described, and data on risk factors for carriage are conflicting. Here, we report the prevalence and population ...
    • The first tigecycline resistant Enterococcus faecium in Norway was related to tigecycline exposure 

      Hegstad, Kristin; Pöntinen, Anna Kaarina; Bjørnholt, Jørgen; Paulsen, Else Quist; Sundsfjord, Arnfinn Ståle (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-12-19)
      Objectives - We describe the first tigecycline resistant enterococcal isolate in Norway and the mechanisms involved.<p> <p>Material and methods - The Norwegian National Advisory Unit on Detection of Antimicrobial Resistance (K-res). received in 2022 an Enterococcus faecium blood culture isolate with decreased susceptibility to tigecycline from a hospitalized patient in the South-Eastern Norway ...
    • The first vanE-type vancomycin resistant Enterococcus faecalis isolates in Norway – phenotypic and molecular characteristics 

      al Rubaye, Mushtaq Talib Shawi; Janice, Jessin; Bjørnholt, Jørgen; Löhr, Iren Høyland; Sundsfjord, Arnfinn Ståle; Hegstad, Kristin (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-12-27)
      Objectives - We aimed to characterize the vanE cluster and its genetic support in the first Norwegian vanE-type isolates and assess genetic relatedness to other vanE isolates.<p> <p>Methods - Two vanE-type vancomycin resistant Enterococcus faecalis (vanE-VREfs) isolates (E1 and E2) recovered from the same patient 30 months apart were examined for antimicrobial susceptibility, genome sequence, ...
    • The population structure of vancomycin-resistant and -susceptible Enterococcus faecium in a low-prevalence antimicrobial resistance setting is highly influenced by circulating global hospital-associated clones 

      al Rubaye, Mushtaq Talib Shawi; Janice, Jessin; Bjørnholt, Jørgen; Kacelnik, Oliver; Haldorsen, Bjørg C; Nygaard, Randi Monsen; Hegstad, Joachim; Sundsfjord, Arnfinn Ståle; Hegstad, Kristin (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-09-19)
      Between 2010 and 2015 the incidence of vancomycin-resistant Enterococcus faecium (VREfm) in Norway increased dramatically. Hence, we selected (1) a random subset of vancomycin-resistant enterococci (VRE) from the Norwegian Surveillance System for Communicable Diseases (2010–15; n=239) and (2) Norwegian vancomycin-susceptible E. faecium (VSEfm) bacteraemia isolates from the national surveillance ...